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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Chicoric acid, TNF-related apoptosis inducing ligand
Phytochemical Name Chicoric acid (PubChem CID: 5281764 )
Anticancer drug Name TNF-related apoptosis inducing ligand (PubChem CID: / )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 334
Ref_1
Pair Name Chicoric acid, TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Activity CASP3 hsa836
Down-regulation Expression MAP2K7 hsa5609
Up-regulation Activity MAPK8 hsa5599
Down-regulation Expression TIPRL hsa261726
In Vitro Model Huh-7 Adult hepatocellular carcinoma Homo sapiens (Human) CVCL_0336
Result Our results suggest that TO plays an important role in TRAIL-induced apoptosis, and further functional studies are warranted to confirm the importance of TO as a novel TRAIL sensitizer for cancer therapy.
03. Reference
No. Title Href
1 Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells. Mol Carcinog. 2016;55(4):387-396. doi:10.1002/mc.22288 Click
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